D-STAR (Digital Smart Technologies for Amateur Radio) is a digital voice and data protocol specification for amateur radio. The system was developed in the late 1990s by the Japan Amateur Radio League and uses minimum-shift keying in its packet-based standard. There are other digital modes that have been adapted for use by amateurs, but D-STAR was the first that was designed specifically for amateur radio.
The D-STAR Info page is a good place to start for information about this mode of operation. A very good PDF on DStar can be found here.